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space flight poses many challenges to

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the human body in space so the long-term

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goal of our research is to get to a

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place where we can maintain the health

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oxidative stress is when we have too

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much

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of reactive forms of oxygen in the body

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there are studies being done

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on astronauts collecting samples to

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measure

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changes in molecules that reflect

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oxidative damage the benefits of working

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with animals is that we're able to

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really get at

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test mechanisms for disease processes so

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by mechanisms what i mean is how it is

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we go from step a to step b to step c to

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end up with an adverse state when going

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into space when weightless

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there's bone loss muscle loss and the

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cardiovascular system deconditions

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having too much oxidative stress

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can lead to disease

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oxidative stress is thought to be

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involved in things like alzheimer's and

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cardiovascular disease

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[Music]

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there's a lot of interest

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in understanding what role oxidative

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stress has in some of the changes that

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occur

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we work with mice doing studies to get a

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better understanding of how

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those bone changes and other changes in

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the body occur in the space environment

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experiments that are done on earth to

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develop drugs or to understand disease

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processes on earth mice or rats are

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exposed to changes in their environment

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that simulate rodent research is is

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beneficial all these things can be

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studied in animals

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to get a better understanding of how the

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deficits occur in astronauts

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by studying these things like bone loss

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and muscle loss we gain further insight

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into how it's happening and also how to

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treat it and the way we treat it in